According to the results of a new study, opioids and selective inhibitors of serotonin reuptake (SSRIs) are associated with a higher risk of osteoporotic fractures in patients with rheumatoid arthritis (RA).
Chronic inflammation and pain predispose patients with RA to multiple related diseases, including cardiovascular, psychiatric, and gastrointestinal disorders that lead to frequent use of multiple medications. Some of these drugs affect the risk of fracture in the General population, but these associations have not been studied in patients with RA.
Researchers from the University of Nebraska at Omaha, examined data 11049 patients with RA age 40 years and older who have not had fractures. During the observation period, which averaged 5.7 years, 863 patients received osteoporotic fracture.
The results of the study showed that patients who received fractures were significantly older and had higher disease activity, longer duration of disease, higher rates of use of glucocorticoids, higher risk of fracture and greater comorbidities at baseline than patients who did not have fractures.
The researchers also found a significant increase in the risk of osteoporotic fracture, if the patient used opioids or SSRIs. The participants had an increased risk of fractures after 30 days of administration of opioids, whereas the risk of fractures associated with the use of SSRIs started to grow 3 months after you start taking these antidepressants.
Scientists came to the conclusion that the high risk of fracture associated with the use of opioids or SSRIs, may be due to an increased risk of falls associated with these drugs.
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